Glutathione
Glutathione is the body's most abundant endogenous antioxidant, a tripeptide involved in detoxification, immune function, and protection against oxidative stress. Levels decline with age and chronic illness, and oral/IV supplementation has been studied in a number of randomized controlled trials.
- Supports the body's primary antioxidant defense
- Studied for liver detoxification support
- Researched in skin brightness and cellular health
No commitment · Cancel anytime · Physician evaluation required
About Glutathione
Glutathione (GSH) is a tripeptide made from glutamate, cysteine, and glycine, synthesized in nearly every cell in the body. It plays a central role in neutralizing free radicals, supporting liver detoxification pathways, and maintaining immune cell function.
What the research shows
Human RCT evidence for glutathione is more developed than for many peptides in this category. A 6-month randomized, double-blind, placebo-controlled trial in 54 healthy adults found oral glutathione supplementation increased blood glutathione stores by 30-35% in plasma and red blood cells. A separate randomized trial in elderly type 2 diabetic patients found 6 months of glutathione supplementation reduced oxidative DNA damage markers and helped stabilize HbA1c. It's worth noting most controlled trial data uses oral glutathione; injectable/IV administration — the form offered here — has a longer history of clinical and cosmetic use but fewer dedicated controlled trials isolating the injectable route specifically.
Who it's for
Glutathione is often considered by adults focused on antioxidant support, liver health, or as a complement to a broader wellness or GLP-1 program.
How It's Administered
Glutathione is typically administered as a subcutaneous or intramuscular injection on a schedule determined by your physician during your evaluation.
Safety & Considerations
Oral and injectable glutathione has a generally favorable safety record across clinical trials, which report mild and infrequent side effects. IV glutathione specifically has been associated with rare but serious reactions including anaphylaxis in case reports, which is why physician oversight and proper administration matter.
Your physician will review your health history during your evaluation. Not all applicants will qualify.
Selected References
The following peer-reviewed sources informed the summary above. Evidence quality varies — some reflect large controlled human trials, others early-stage or animal research, as noted.
- Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
PubMed, 2015 - Randomized Clinical Trial of How Long-Term Glutathione Supplementation Offers Protection from Oxidative Damage and Improves HbA1c in Elderly Type 2 Diabetic Patients
PMC (National Institutes of Health), 2022